Kamijyo akimine biography of michael jackson

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We produced transgenic mice that express a dominant-positive truncated form of sterol regulatory element-binding protein-2 (SREBP-2) in liver and adipose tissue. The encoded protein lacks the membrane-binding and COOH-terminal regulatory domains, and it is therefore not susceptible to negative regulation by cholesterol. Livers from the transgenic mice showed increases in mRNAs encoding multiple enzymes of cholesterol biosynthesis, the LDL receptor, and fatty acid biosynthesis. The elevations in mRNA for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase and HMG CoA reductase were especially marked (13-fold and 75-fold, respectively). As a result, the transgenic livers showed a 28-fold increase in the rate of cholesterol synthesis and a lesser fourfold increase in fatty acid synthesis, as measured by intraperitoneal injection of [3H]water. These results contrast with previously reported effects of dominant-positive SREBP-1a, which activated fatty acid synthesis more than cholesterol synthesis. In adipose tissue of the SREBP-2 transgenics, the mRNAs for cholesterol biosynthetic enzymes were elevated, but the mRNAs for fatty acid biosynthetic enzymes were not. We conclude that SREBP-2 is a relatively selective activator of cholesterol synthesis, as opposed to fatty acid synthesis, in liver and adipose tissue of mice.

J D Horton, I Shimomura, M S Brown, R E Hammer, J L Goldstein, H Shimano

Volume 10 - 2nd and later printings. "Secrets!" Collects Blade of the Immortal (1996-2007) #58-65.

Story and Art by Hiroaki Samura.

Anotsu Kagehisa, murderous leader of the rogue Ittö-ryü, has journeyed to the mountains far from Edo to the remote Shingyötö-ryü dojo under invitation to bring the sword school under his wing. But instead of a warm welcome, Anotsu finds a dojo full of angry young men who don't want to take orders from an upstart, unless he can proves he's tougher than the best of them! That sits just fine with Anotsu, who has dedicated his life to putting the killing back into Japan's formalized sword schools, but Anotsu suspects that something more than proof of his worthiness lies beneath the challenge. Meanwhile, the immortal swordsman, Manji, is recovering from a battle that left him literally cut to pieces. His charge, Rin, is till nowhere to be found, bound for vengeance against Anotsu, but soon his troubles may become a bit more immediate, troubles that even an immortal may not survive!

Softcover, 232 pages, 5 1/2-in. x 8 1/4-in., B&W.

Cover price $16.95.